• MELODI is a hypothesis generator. It identifies enriched overlapping objects which have been assigned to scientific literature and uses these to derive intermediate mechanisms.
  • The underlying annotation objects used for the analysis are semantic predications from the Semantic MEDLINE Datatabase (SemMedDB) and Medical Subject Headings (MeSH).
  • Please read the About page to find out more about how to use the application and click on the blue information button at the top of any page for more information.
  • Data are stored and investigated using a graph.

To perform a new analysis please Sign in, or to explore some pre-loaded analyses select some results from table below.



Concept 1 Concept 2 Date Method1 Method2 Method3
TMPRSS2ERG or ERG Prostate cancer 2017-11-08 22:34:45 meshMain:2023 semmed_c:2024 semmed_t:2025
NF1 Marfan syndrome 2017-11-07 12:40:29 meshMain:1999 semmed_c:2000 semmed_t:2001
Dehydration Kidney disease 2017-11-09 15:18:08 meshMain:2086 semmed_c:2087 semmed_t:2088
Pesticide kidney disease 2017-11-09 11:58:28 meshMain:2035 semmed_c:2036 semmed_t:2037
Selenium Prostate cancer 2017-11-08 13:12:07 meshMain:2011 semmed_c:2012 semmed_t:2013
PCSK9 Marfan syndrome 2017-11-07 12:31:53 meshMain:1993 semmed_c:1994 semmed_t:1995
BRCA2 Pancreatic cancer 2017-11-07 12:40:07 meshMain:1996 semmed_c:1997 semmed_t:1998

Database/User Details ()

News and Updates

29/03/18Updated SemMedDB to latest version (December 31 2017). Graph now contains data from ~400,000 more PubMed articles.
27/03/18NCBI server downtime was bad news for MELODI today. Apologies if any jobs did not run :(
12/01/18MELODI Published in IJE - https://academic.oup.com/ije/advance-article-abstract/doi/10.1093/ije/dyx251/4803214
23/08/17Updated SemMedDB to Version 30.2 (June 30 2017). Graph now contains data from ~700,000 more PubMed articles.
20/03/17MELODI Published in biorxiv - http://biorxiv.org/content/early/2017/03/20/118513
30/01/17List of filtered concepts now available to download.
23/01/17Third analysis option included - SemMedDB concepts.
18/01/17Can now delete unwanted article sets
13/12/16Switched multiple correction method to Benjamini/Hochberg (non-negative) with a 1e-5 cutoff
09/12/16Updated concept frequencies per year for MeSH data
21/11/16Updated SemMedDB to Version 26 (April 30th 2016). Graph now contains ~700,000 more PubMed articles.
09/11/16Added option to share a results page.
26/09/16MELODI presented at Big Data in Biology and Health.
06/09/16Improved performance by modifying graph installation.