- MELODI is a hypothesis generator. It identifies enriched overlapping objects which have been assigned to scientific literature and uses these to derive intermediate mechanisms.
- The underlying annotation objects used for the analysis are semantic predications from the Semantic MEDLINE Datatabase (SemMedDB) and Medical Subject Headings (MeSH).
- Please read the About page to find out more about how to use the application and click on the blue information button at the top of any page for more information.
- Data are stored and investigated using a graph.
To perform a new analysis please Sign in, or to explore some pre-loaded analyses select some results from table below.
|Concept 1||Concept 2||Date||Method1||Method2||Method3|
|TMPRSS2ERG or ERG||Prostate cancer||2017-11-08 22:34:45||meshMain:2023||semmed_c:2024||semmed_t:2025|
|NF1||Marfan syndrome||2017-11-07 12:40:29||meshMain:1999||semmed_c:2000||semmed_t:2001|
|Dehydration||Kidney disease||2017-11-09 15:18:08||meshMain:2086||semmed_c:2087||semmed_t:2088|
|Pesticide||kidney disease||2017-11-09 11:58:28||meshMain:2035||semmed_c:2036||semmed_t:2037|
|Selenium||Prostate cancer||2017-11-08 13:12:07||meshMain:2011||semmed_c:2012||semmed_t:2013|
|PCSK9||Marfan syndrome||2017-11-07 12:31:53||meshMain:1993||semmed_c:1994||semmed_t:1995|
|BRCA2||Pancreatic cancer||2017-11-07 12:40:07||meshMain:1996||semmed_c:1997||semmed_t:1998|
News and Updates
|29/03/18||Updated SemMedDB to latest version (December 31 2017). Graph now contains data from ~400,000 more PubMed articles.|
|27/03/18||NCBI server downtime was bad news for MELODI today. Apologies if any jobs did not run :(|
|12/01/18||MELODI Published in IJE - https://academic.oup.com/ije/advance-article-abstract/doi/10.1093/ije/dyx251/4803214|
|23/08/17||Updated SemMedDB to Version 30.2 (June 30 2017). Graph now contains data from ~700,000 more PubMed articles.|
|20/03/17||MELODI Published in biorxiv - http://biorxiv.org/content/early/2017/03/20/118513|
|30/01/17||List of filtered concepts now available to download.|
|23/01/17||Third analysis option included - SemMedDB concepts.|
|18/01/17||Can now delete unwanted article sets|
|13/12/16||Switched multiple correction method to Benjamini/Hochberg (non-negative) with a 1e-5 cutoff|
|09/12/16||Updated concept frequencies per year for MeSH data|
|21/11/16||Updated SemMedDB to Version 26 (April 30th 2016). Graph now contains ~700,000 more PubMed articles.|
|09/11/16||Added option to share a results page.|
|26/09/16||MELODI presented at Big Data in Biology and Health.|
|06/09/16||Improved performance by modifying graph installation.|